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Observed native liver survival over time in patients with a BSEP1/1, BSEP1/3 and BSEP3/3 genotype.
(A) All patients. (B) Patients without siEHC during follow-up, patients with siEHC are censored at time of siEHC. (C) Patients after they had siEHC. Genotypic categorization of BSEP1/1, BSEP1/3 and BSEP3/3 groups is defined in the methods section. Log-rank tests. BSEP, bile salt export pump; siEHC, surgical interruption of the enterohepatic circulation.
