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. 2022 Dec 23;28:88–103. doi: 10.1016/j.omto.2022.12.005

Figure 1.

Figure 1

BBOX1-AS1 is upregulated in HCC tissues

(A) qRT-PCR analysis of BBOX1-AS1 expression in HCC tissues and matched adjacent normal tissues (n = 83). (B) The relative expression of BBOX1-AS1 in 83 paired tissues [log2(T/N)]. (C) BBOX1-AS1 expression in normal human liver cell line HL7702 and six HCC cell lines (97H, HepG2, Hep3B, HLF, LM3 and Huh7). (D) BBOX1-AS1 expressions were compared between patients without microvascular invasion (MVI) and those with MVI (n = 83). (E) BBOX1-AS1 expression in the TNM stage I/II patients and the TNM III/IV patients (n = 83). (F) Kaplan-Meier survival curve was used to explore the effect of BBOX1-AS1 on overall survival (n = 83). (G) Cox proportional hazards analysis of the independent predictive factors for overall survival (n = 83). (H) FISH was used to explore BBOX1-AS1 expression in HCC tissues and matched adjacent normal tissues. (I) FISH was used to explore BBOX1-AS1 expression in HCC cells. (J) The expression level of BBOX1-AS1 in the subcellular fractions of HCC cells was detected by qRT-PCR. ∗∗p < 0.01, ∗∗∗p < 0.001; N, normal tissue; T, tumor tissue.