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Vaccination with plasmid pCPA or pCLF4 or a combination of these plasmids confers protection against lethal anthrax toxin challenge
| Challenge dose/mouse | LD50 | No. of survival/no. of mice immunized with plasmid DNAa
|
|||
|---|---|---|---|---|---|
| Vector | pPA | pLF4 | pLF4 + pPA | ||
| 60 μg of PA, 25 μg of LF4 | 5 | 0/3 | 3/3 | 3/3 | 4/4 |
A mixture of PA and LF was injected intravenously into multiply immunized or vector-treated BALB/c mice.
