Table 2.
Multivariate Cox regression analysis for overall survival (OS) and breast cancer-specific survival (BCSS) of BCLM patients in the training cohort.
| Variables | OS | BCSS | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | Points | HR (95% CI) | P-value | Points | |
| Sex | ||||||
| Female | – | – | – | – | – | – |
| Male | – | – | – | – | – | – |
| Age | ||||||
| <40 | Reference | 0 | Reference | 0 | ||
| 40–59 | 1.288 (1.005–1.651) | 0.0453 | 19 | 1.322 (1.019–1.715) | 0.0358 | 20 |
| 60–79 | 1.480 (1.155–1.897) | 0.0020 | 30 | 1.427 (1.099–1.854) | 0.0077 | 26 |
| 80+ | 2.458 (1.844–3.277) | 0.0000 | 68 | 2.264 (1.666–3.078) | 0.0000 | 60 |
| Marital status | ||||||
| Married | Reference | 0 | Reference | 0 | ||
| Unmarried | 1.319 (1.177–1.478) | 0.0000 | 21 | 1.2991.151–1.466) | 0.0000 | 19 |
| Race | ||||||
| White | Reference | 14 | Reference | 15 | ||
| Black | 1.228 (1.065–1.415) | 0.0047 | 30 | 1.184 (1.017–1.377) | 0.0293 | 27 |
| Other | 0.833 (0.678–1.023) | 0.0819 | 0 | 0.814 (0.653–1.014) | 0.0660 | 0 |
| Site | ||||||
| Inner | – | – | – | – | – | – |
| Outer | – | – | – | – | – | – |
| Other | – | – | – | – | – | – |
| Laterality | ||||||
| Left | Reference | 0 | Reference | 0 | ||
| Right | 1.160 (1.041–1.293) | 0.0074 | 11 | 1.163 (1.036–1.306) | 0.0104 | 11 |
| Grade | ||||||
| I-II | Reference | 0 | Reference | 0 | ||
| III-IV | 1.402 (1.236–1.590) | 0.0000 | 26 | 1.493 (1.304–1.709) | 0.0000 | 20 |
| AJCC_T | ||||||
| T1-2 | Reference | 0 | Reference | 0 | ||
| T3-4 | 1.307 (1.164–1.468) | 0.0000 | 20 | 1.354 (1.196–1.534) | 0.0000 | 22 |
| AJCC_N | ||||||
| N0 | – | – | – | – | – | – |
| N1-3 | – | – | – | – | – | – |
| Subtype | ||||||
| HR+/HER2− | Reference | 18 | Reference | 18 | ||
| HR+/HER2+ | 0.789 (0.669–0.930) | 0.0048 | 0 | 0.777 (0.652–0.926) | 0.0047 | 0 |
| HR−/HER2+ | 1.207 (0.982–1.485) | 0.0738 | 32 | 1.102 (0.881–1.377) | 0.3950 | 26 |
| HR−/HER2− | 2.937 (2.492–3.462) | 0.0000 | 100 | 3.051 (2.566–3.629) | 0.0000 | 100 |
| Bone | ||||||
| No | Reference | 0 | Reference | 0 | ||
| Yes | 1.355 (1.198–1.532) | 0.0000 | 23 | 1.3206 (1.1583–1.5057) | 0.0000 | 20 |
| Brain | ||||||
| No | Reference | 0 | Reference | 0 | ||
| Yes | 1.926 (1.618–2.294) | 0.0000 | 50 | 1.9160 (1.593–2.305) | 0.0000 | 48 |
| Liver | ||||||
| No | Reference | 0 | Reference | 0 | ||
| Yes | 1.644 (1.451–1.863) | 0.0000 | 38 | 1.778 (1.559–2.028) | 0.0000 | 42 |
| Surgery | ||||||
| No | Reference | 20 | Reference | 21 | ||
| Yes | 0.770 (0.680–0.872) | 0.0000 | 0 | 0.747 (0.654–0.853) | 0.0000 | 0 |
| Chemotherapy | ||||||
| No/Unknown | Reference | 35 | Reference | 32 | ||
| Yes | 0.633 (0.556–0.721) | 0.0000 | 0 | 0.648 (0.563–0.745) | 0.0000 | 0 |
| Radiation | ||||||
| No/Unknown | – | – | – | – | – | – |
| Yes | – | – | – | – | – | – |