TABLE 2.
Main pharmacokinetics parameters of cyclosporin in three groups of rats (n = 6).
| Parameter | Cyclosporin (40 mg/kg) | Cyclosporin (40 mg/kg) + nimodipine (24 mg/kg) | Cyclosporin (40 mg/kg) + nisoldipine (2 mg/kg) |
|---|---|---|---|
| AUC(0-t) (μg/L·h) | 19,032.20 ± 7,160.00 | 32,075.93 ± 8,210.72* | 18,919.37 ± 5,668.04 |
| AUC(0-∞) (μg/L·h) | 22,523.78 ± 2,530.32 | 32,337.21 ± 8,156.34* | 22,224.93 ± 6,085.61 |
| t1/2z (h) | 7.97 ± 3.24 | 6.62 ± 0.94 | 13.04 ± 2.56* |
| Tmax (h) | 6.00 ± 1.10 | 5.67 ± 1.86 | 5.00 ± 1.67 |
| Vz/F (L/kg) | 20.37 ± 6.95 | 13.11 ± 6.54 | 34.82 ± 6.79** |
| CLz/F (L/h/kg) | 1.79 ± 0.19 | 1.33 ± 0.46* | 1.91 ± 0.48 |
| Cmax (μg/L) | 1,690.51 ± 373.77 | 1,933.95 ± 382.31 | 1,244.62 ± 194.62 |
AUC, area under the blood concentration–time curve; t1/2z, elimination half time; Tmax, peak time; Vz/F, apparent volume of distribution; CLz/F, blood clearance; Cmax, maximum blood concentration.
*p < 0.05, in comparison with the control group.