TABLE 3.
Main pharmacokinetics parameters of AM1 in three groups of rats (n = 6).
| Parameter | Cyclosporin (40 mg/kg) | Cyclosporin (40 mg/kg) + nimodipine (24 mg/kg) | Cyclosporin (40 mg/kg) + nisoldipine (2 mg/kg) |
|---|---|---|---|
| AUC(0-t) (μg/L·h) | 2,275.37 ± 620.96 | 3,291.60 ± 1,213.46 | 1,548.46 ± 482.43* |
| AUC(0-∞) (μg/L·h) | 2,542.74 ± 779.21 | 3,504.89 ± 1,223.40 | 2,128.73 ± 887.82 |
| t1/2z (h) | 12.10 ± 9.00 | 10.83 ± 3.52 | 19.58 ± 13.45 |
| Tmax (h) | 6.83 ± 1.33 | 7.00 ± 2.68 | 6.17 ± 1.60 |
| Vz/F (L/kg) | 264.78 ± 145.01 | 198.16 ± 99.97 | 494.23 ± 201.15* |
| CLz/F (L/h/kg) | 17.03 ± 5.31 | 12.42 ± 3.60 | 21.26 ± 7.31 |
| Cmax (μg/L) | 141.21 ± 30.64 | 192.68 ± 69.42 | 110.32 ± 19.52 |
AUC, area under the blood concentration–time curve; t1/2z, elimination half time; Tmax, peak time; Vz/F, apparent volume of distribution; CLz/F, blood clearance; Cmax, maximum blood concentration.