Table 4.

Single variant results for IL33.

Variant1	Chr2	Pos3	Gene4	P-value5	MAF6	Direction7	Annotation8
rs555998964	9	6215178	IL33	0.229	0.005	+	UTR5
rs746808236	9	6215231	IL33	0.608	0.005	–	intronic
rs1431798023	9	6215727	IL33	0.125	0.005	+	intronic
rs17498168	9	6237186	IL33	0.211	0.028	–	intronic
NA	9	6250936	IL33	0.496	0.037	–	intronic
rs1317230	9	6251012	IL33	0.205	0.317	–	intronic
rs73398552	9	6252689	IL33	0.039	0.041	+	intronic
rs149045797	9	6252690	IL33	0.535	0.005	–	intronic
rs1397714619	9	6252710	IL33	0.142	0.005	+	intronic
NA	9	6252720	IL33	0.142	0.005	+	intronic
rs10975519	9	6253571	IL33	0.861	0.367	+	exonic (synonymous)
rs562550122	9	6253690	IL33	0.068	0.005	+	intronic
rs10975520	9	6253710	IL33	0.660	0.358	+	intronic
NA	9	6255774	IL33	0.626	0.005	–	intronic
NA	9	6255781	IL33	0.626	0.005	–	intronic
rs12336076	9	6255789	IL33	0.602	0.321	–	intronic
NA	9	6255807	IL33	0.600	0.239	–	intronic
NA	9	6255808	IL33	0.785	0.028	–	intronic
NA	9	6255814	IL33	0.784	0.028	–	.
rs1013300156	9	6255821	IL33	0.819	0.133	+	intronic
NA	9	6255826	IL33	0.870	0.101	–	intronic
rs1332290	9	6255881	IL33	0.403	0.417	+	intronic
rs146597587	9	6255967	IL33	0.535	0.005	–	splicing
rs1240440599	9	6256010	IL33	0.732	0.005	–	exonic (synonymous)
NA	9	6256013	IL33	0.732	0.005	–	exonic (synonymous)
rs35375147	9	6256078	IL33	0.344	0.014	–	exonic (synonymous)
rs1048274	9	6256292	IL33	0.835	0.372	–	UTR3
NA	9	6256471	IL33	0.542	0.050	–	UTR3
NA	9	6256476	IL33	0.789	0.023	+	UTR3
rs55726619	9	6256678	IL33	0.039	0.041	+	UTR3
NA	9	6256741	IL33	0.035	0.005	+	UTR3
rs12000491	9	6257367	IL33	0.039	0.041	+	UTR3
rs189961633	9	6257571	IL33	0.787	0.009	+	UTR3
NA	9	6257597	IL33	0.099	0.014	+	UTR3
rs553100713	9	6257606	IL33	0.068	0.009	+	UTR3
NA	9	6257718	IL33	0.607	0.005	–	UTR3
rs73398574	9	6257724	IL33	0.039	0.041	+	UTR3

¹Variant identification number (rsID), if assigned. Nominally significant associations with allergic asthma are presented in bold.

²Chromosome.

³Base pair position on the chromosome, in hg38 coordinates.

⁴Gene in which the variant was identified.

⁵P-value from the SKAT test.

⁶Minor Allele Frequency.

⁷Direction of effect estimated using logistic regression, where “+” represents a variant with a minor allele that has a higher frequency among asthmatic children and “-” represents a variant with a minor allele that has a lower frequency among asthmatic children.

⁸Functional annotation according to refGene; UTR3 = 3’ untranslated region; UTR5 = 5’ untranslated region.