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. 2023 Jan 6;13:1039850. doi: 10.3389/fgene.2022.1039850

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Copyright © 2023 Cai, Si, Wang and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNAScope validation of development-associated upregulated or downregulated DEGs. (A) Venn diagram showing the amount of shared upregulated or downregulated DEGs among comparison group E11.5 vs. E10.5, E12.5 vs. E11.5, and E12.5 vs. E10.5. (B) Heatmap showing the top ten shared upregulated or downregulated DEGs among E10.5, E11.5, and E12.5. Color key: expression levels, (C) GO terms for shared upregulated (left) and downregulated (right) DEGs from E10.5 to E12.5. (D) RNAScope analysis of the location and expression levels of candidate genes among E10.5, E11.5, and E12.5. MxP: maxillary prominence; LNP: lateral nasal; MNP: medial nasal.