TABLE 2.
Details of the five candidate genes identified by TWAS.
| Gene | Chr | Start a | End a | Effect ± SD b | p-value c | h2 ± SD d |
|---|---|---|---|---|---|---|
| PPAT | 6 | 71,782,614 | 71,821,764 | -0.0031 ± 0.00089 | 7.68E-05 | 0.76 ± 0.32 |
| MTMR3 | 17 | 68,971,211 | 69,102,722 | -0.0060 ± 0.00020 | 9.11E-05 | 0.61 ± 0.31 |
| FGFRL1 | 6 | 117,346,407 | 117,358,800 | 0.0020 ± 0.00068 | 1.17E-04 | 0.58 ± 0.30 |
| DHRS4 | 10 | 21,088,232 | 21,100,627 | -0.0069 ± 0.0022 | 1.26E-04 | 0.68 ± 0.32 |
| LAP3 | 3 | 37,140,752 | 37,166,191 | 0.018 ± 0.0031 | 1.32E-04 | 0.70 ± 0.34 |
a
The SNP position (bp) on ARS-UCD1.2.
b
The effects of gene expression calculated by LMM in TWAS.
c
p-values calculated by LMM.
d
The heritability of gene expression calculated by REML.