Skip to main content
. 2023 Jan 6;13:1098408. doi: 10.3389/fphys.2022.1098408

FIGURE 5.

FIGURE 5

ApoE −/− vessels exhibit hyperpermeability. (A–B) Increased leak of Evan’s Blue dye is evident in vivo in ApoE −/− vessels (B) compared to ApoE +/+ vessels (A). Arrows mark sites of leakage. (C) Ex vivo quantification of albumin permeability (Ps) for ApoE +/+ vessels (n = 15) and ApoE −/− vessels (n = 20). The averages were 21 × 10–7 cm/s vs. 109 × 10–7 cm/s for the controls vs. knockouts, respectively, which was significantly different based on a Mann-Whitney test. There was high variability in the ApoE −/− group, with 8 of 20 ApoE −/− vessels having severely elevated permeability (statistically significant by Mann-Whitney test) compared to ApoE +/+ vessels when the data were split into subpopulations, and 12 of 20 vessels were within the range of ApoE +/+ vessels (not significantly different by Mann-Whitney test).