Table 5.
Representative pathways identified by the Reactome-PA database.
| Reactome Pathway ID | Pathway Description | Gene Ratio (miRNA target / pathway genes) | p-value | Target Gene List |
|---|---|---|---|---|
| R-HSA-9006931 | Signaling by Nuclear Receptors | 13/299 | 1.44E-06 | AKT1/BCL2/CDKN1B/ESR1/FASN/FOXO3/HSP90A A1/MYC/PIK3R1/AGO1/AGO2/TNRC6A/MYLIP |
| R-HSA-1257604 | PIP3 activates AKT signaling | 12/267 | 2.68E-06 | AKTI/XIAP/CDKNIB/ESR1/FOXO3/PIK3R1/RACI/ FRS2/AGO1/AGO2/TNRC6A/CBX2 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 8/108 | 3.71E-06 | AKTI/BCL2/FOXO3/HSP90AA1/MYC/PIK3R1/VCA MI/VEGFA |
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | 4/15 | 6.38E-06 | AKTI/BCL2/YWHAE/YWHAH |
| R-HSA-8934593 | Regulation of RUNX1 expression and activity | 4/17 | 1.10E-05 | CDK6/AGO1/AGO2/TNRC6A |
| R-HSA-9607240 | FLT3 signaling | 5/38 | 1.65E-05 | AKTI/CDKNIB/FOXO3/PIK3R1/SOCS6 |
| R-HSA-5663202 | Diseases of signal transduction by growth factor receptors and second messengers | 14/433 | 1.71E-05 | AKTI/CDKNIB/ESRI/FOXO3/HSP90AA1/KIF5B/FZ D6/MYC/PIK3R1/RACI/RAPIB/MIB1/SPRED1 |
| R-HSA-2559583 | Cellular senescence | 9/197 | 4.55E-05 | ATM/CDK6/CDKNIB/HMGA1/HMGA2/AGO1/MIN K1/TNRC6A/CBX2 |
| R-HSA-201556 | Signaling by ALK | 4/27 | 7.59E-05 | PRDM1/MYC/PIK3R1/FRS2 |
| R-HSA-8875555 | MET activates RAP1 and RACI | 3/11 | 9.53E-05 | CRK/RACI/RAPIB |
| R-HSA-5628897 | TP53 regulates metabolic genes | 6/87 | 9.66E-05 | AKTI/YWHAE/YWHAH/AGO1/AGO2/TNRC6A |
| R-HSA-203615 | eNOS activation | 3/13 | 0.00016 | AKT1/HSP90AA1/DDAH1 |
| R-HSA-4420097 | VEGFA-VEGFR2 pathway | 6/99 | 0.0002 | AKT1/CRK/HSP90AA1/PIK3R1/RACI/VEGFA |
| R-HSA-8848021 | Signaling by PTK6 | 4/54 | 0.00115 | AKT1/CDKNIB/CRK/RACI |
| R-HSA-453279 | Mitotic G1 phase and G1/S transition | 6/149 | 0.00172 | AKTI/CDK6/CDKNIB/MYC/RRM2/WEE1 |
| R-HSA-389356 | CD28 co-stimulation | 3/33 | 0.00275 | AKTI/PIK3RI/RACI |