Table 2.

Comparison of pathologies in cognitively normal individuals and cognitively impaired individuals

	Cognitively normal (CDR = 0; n = 79)	Cognitively impaired (CDR ≥ 0.5; n = 625)	p value
ADNC, Int-High	27 (34.2%)	435 (69.6%)	<0.0001
LATE-NC, stages 2–3	11 (13.9%)	204 (32.6%)	0.0004
LBD, stages 2–3	17 (21.5%)	146 (23.4%)	0.7785
Cerebrovascular disease	39 (43.8%)	289 (46.2%)	0.6331
At least 1 proteinopathy	44 (55.7%)	530 (84.8%)	<0.0001
Multiple proteinopathies	13 (16.5%)	221 (35.4%)	0.0006
At least 1 pathology	46 (58.2%)	541 (86.6%)	0.0208
Multiple pathologies	15 (19.0%)	260 (41.6%)	<0.0001