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Serum albumin IHC demonstrates vascular leakage in CTE and RHI-exposed cases, but not in RHI-naïve cases. Albumin IHC staining within the dorsolateral frontal sulcus from 3 RHI-exposed cases (A–D) and 1 RHI-naïve case (E). Positive staining surrounding the microvasculature indicates leakage of serum proteins into parenchyma, while intravascular staining confirms labeling of serum albumin (D).
