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. 2023 Jan 6;13:1020831. doi: 10.3389/fpsyt.2022.1020831

FIGURE 1.

FIGURE 1

Risperidone induces a dose response of motor side effects in aged mice and histone deacetylase (HDAC) inhibitors could prevent the side effects. (A) Motor side effects measured by cataleptic episode in 5 min. Lower dose of RIS at 0.1 mg/kg already showed a significant increase in cataleptic behavior in aged mice but not young mice. However, the higher doses of RIS could cataleptic behavior in both young and aged mice, although more severe in aged mice. (B) General locomotor activity measured by open field. Again, the lower dose of RIS at 0.1 mg/kg displayed a decrease in the distance traveled in aged mice but not in young group. However, higher doses of RIS at 0.5 and 1.0 mg/kg induced the decreased in the distance traveled with a dose respond manner. (C) Co-treatment of lower dose of RIS (0.1 mg/kg) with VPA (400 mg/kg) or MS-275 (10 mg/kg) reduced the duration of catalepsy in aged mice. (D) Lower dose of RIS (0.1 mg/kg) with VPA (400 mg/kg) or MS-275 (10 mg/kg) did mitigate the RIS-induced decrease in locomotor activity in the young but not old mice. Data represent mean ± SEM (n = 6–8/group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.