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. 2023 Jan 6;9:1052540. doi: 10.3389/fmed.2022.1052540

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Copyright © 2023 Meng, Zhu, Jia, Li, Wang and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main regulatory pathways of ferroptosis. There are two main ways of regulating ferroptosis shown in the figure: the first is the pathway of abnormal iron, amino acid, and lipid metabolism; the second involves the related signaling pathways that regulate ferroptosis, such as the P53 and Nrf2 pathways. Glu, glutamic acid; GSH, glutathione; GPX4, glutathione peroxidase 4; Nrf2, Nuclear factor erythroid 2-related factor 2; GLS2, glutaminase 2; LOXs, lipoxygenases; ROS, reactive oxygen species; DMT1, divalent metal ion transporter-1; SAT1, spermidine N1-acetyltransferase 1; TfR, transferrin receptor.