Table 1.
Mechanism of ferroptosis in COPD.
| Reagents | Model | Key mechanisms | References |
|---|---|---|---|
| DFO, Fer-1 | HBEC; COPD mouse model | CS promotes the accumulation of unstable iron via NCOA4-mediated ferritinophagy, inducing lipid peroxidation and ferroptosis | (8) |
| Fer-1, DFOM | EA.hy 926; HUVECs | PM2.5 causes iron overload and oxidative stress and further induces ferroptosis. | (60) |
| Fer-1, DFO, CUR | BEAS-2B; COPD mouse model | CS/CSE causes cell damage and enhances inflammation, and oxidative stress induces ferroptosis | (61) |
| Dihydroquercetin (DHQ); ML385, | HBE cells; COPD mouse model | CSE induces cellular oxidative stress and ferroptosis | (62) |
| Fer-1 | HBE cells; COPD mouse model | CSE induces increased levels of cellular ROS, lipid peroxides, and MDA, with IL-1β and IL-8 inducing ferroptosis and inflammatory responses, respectively | (63) |
| Fer-1 | HBE/THP-M cells; COPD mouse model | NCOA4-induced ferroptosis promotes macrophage M2 polarization | (64) |