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. 2023 Jan 6;12:1063423. doi: 10.3389/fonc.2022.1063423

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Copyright © 2023 Xu, Hao, Ren, Xu, Liu, Song and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histone lysine lactylation site and the production of lactylation. (A) Histone lysine lactylation site. (B) Lactate metabolism can induce epigenetic remodeling through histone lactylation. After lactate produces lactyl-CoA, the lactosyl group is transferred by p300 to the lysine tail of the histone protein, forming a lactylation modification. Lactyl glutathione (LGSH) hydrolyzed to produce lactate, which forms lactylation modifications through non-enzymatic reactions. HDAC1-3 is a potential delactinase. It is unclear which enzymes produce lactyl-CoA and which enzymes recognize histone lactylation.