Figure 1. Cumulative events of VOCO according to qn-HRP and ql-HRP in the medical treatment group.

A) qn-HRP and B) ql-HRP were associated with an increased risk of VOCO in the medical treatment group with FFR>0.80. C) When lesions were divided into 4 groups based on qn-HRP and ql-HRP, the cumulative event of VOCO was higher only in lesions with qn-HRP (+)/ql-HRP (+) than in those with qn-HRP (–)/ql-HRP (–). qn-HRP was defined as a lesion with an MLA <3.3 mm² and plaque burden ≥70.0%, and ql-HRP as with low-attenuation plaque or positive remodelling. CI: confidence interval; HR: hazard ratio; HRP: high-risk plaque; NA: not available; ql-HRP: qualitative HRP; qn-HRP: quantitative HRP; VOCO: vessel-oriented composite outcomes