Table 1.
Questionnaire and timepoints.
| Baseline | Quarterly visit | Annual check-up | Monthly telephone interview | |
|---|---|---|---|---|
| Informed consent | X | |||
| Medical history | X | |||
| Reason for visit (acute / elective) | X | X | X | |
| Symptoms: | ||||
| Cough* | X | X | X | X |
| Sputum* | X | X | X | X |
| Respiratory infection* | X | X | X | X |
| Fever (≥38°C)* | X | X | X | X |
| Dyspnea* | X | X | X | X |
| Activity* | X | X | X | X |
| Weight / appetite* | X | X | X | X |
| Changes in sinonasal symptoms* | X | X | X | X |
| Changes in gastrointestinal symptoms* | X | X | X | X |
| Hospitalizations | X | X | X | X |
| Medication: | ||||
| Antibiotics* | X | X | X | X |
| Inhalations | X | X | X | X |
| Gastrointestinal | X | X | X | X |
| CFTR Modulators | X | X | X | X |
| CFQ-R | X | X | X | |
| CF-typical complications | X | X | X |
CFTR, Cystic Fibrosis Transmembrane Conductance Regulator; CFQ-R, Cystic Fibrosis Questionnaire-Revised.
*
these symptoms are criteria to define an event as pulmonary exacerbation.