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. 2023 Jan 6;13:1088732. doi: 10.3389/fphar.2022.1088732

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Copyright © 2023 Han, Wu, Zhang, Liang, Xia and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of the risk model in the GEO cohort. (A) Distribution of patients in the GEO cohort based on the median risk score of the TARGET cohort. (B) The survival status for each patient (left side of the dotted line: low-risk population; right side of the dotted line: high-risk population). (C) The PCA plot for osteosarcoma. (D) The t-SNE analysis based on the risk score. (E) Kaplan–Meier curves for comparison of the overall survival between low- and high-risk groups. (F) Time-dependent ROC curves for osteosarcoma.