TABLE 2.
Cytokines associated with T. solium metacestode-induced granulomas
| Tissue identification | Number of cells positive for each cytokinea
|
|||
|---|---|---|---|---|
| IFN-γ | IL-18 | IL-4 | TGF-β | |
| Controls | —b | — | — | 1 |
| P | >150 | 37 ± 2.9 | 30.1 ± 7.6 | >150 |
| A | >150 | 39 ± 2.9 | NDc | >150 |
| D | >150 | 54 ± 3.3 | ND | >150 |
| E | >150 | ND | ND | >150 |
| J | >150 | ND | ND | >150 |
| L | >150 | 41 ± 2.3 | 34.7 ± 3.6 | ND |
| M | >150 | ND | 31.2 ± 6.9 | ND |
| N | >150 | ND | 26.3 ± 4.2 | ND |
a
Cyst-infected human brain tissues P, A, D, E, J, and L and two noninfected controls were subjected to immunohistochemical analysis to determine the presence of cytokines in the granulomas surrounding T. solium cysts. The control tissues did not contain granulomas. Cells were counted as described in Materials and Methods and the data are presented as the average number of cells per 6.25 × 10−2 mm2 of infiltrated tissue ± SEM.
b
—, not detectable.
c
ND, not determined.