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. 2023 Jan 17;11(1):e005319. doi: 10.1136/jitc-2022-005319

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Tasquinimod therapy resulted in increased trabecular bone volume in vivo. (A) Three-dimensional reconstructions of micro-CT scans of the representative femur from vehicle (A1) and tasquinimod-treated 5TGM1 mice (A2). (B) Percentage of bone volume over total volume or bone volume fraction (BV/TV). (C) Trabecular number (Tb.N). (D) Surface density (BS/TV). (E) Trabecular thickness (Tb. Th). (F) Cortical bone volume (C. BV). **p<0.01, ***p<0.001, ****p<0.0001, Mann-Whitney U test. Error bars indicate SD, n=10 per group.