Figure 1.

Flow diagram illustrating cohort inclusion. ICI-nephritis, ICI-treated controls, and hemodynamic AKI controls were used to generate ROC for diagnostic performance of sIL-2R in ICI-nephritis; ICI-nephritis and ICI-treated controls were compared with generate ROC for diagnostic performance of peripheral T and B cell marker changes in ICI-nephritis. The four pathology cohorts were compared in nanostring analysis using historical data. *ICI-treated controls had normal kidney function and no history of immune related adverse events at the time of inclusion. **Clinically ICI-nephritis requires agreement of the diagnosis between two nephrologists during independent chart review. †Four out of the seven patients from the clinical cohort who underwent kidney biopsy were also included in the pathology cohort. AKI, acute kidney injury; ICI, immune checkpoint inhibitor; ROC, receiver operating characteristic.