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. 2023 Jan 19;11(1):e006222. doi: 10.1136/jitc-2022-006222

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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sIL-2R levels and diagnostic performance in patients with ICI-nephritis.(A) Peripheral blood sIL-2R level, shown as fold ULN for each patient group as indicated. Dotted line indicates the optimal cut-off point determined by receiving operating characteristic (ROC) curve analysis (1.75-fold ULN, (B)). Symbols represent unique individuals, bars represent medians (±IQRs) of total indicated patients. ANOVA test with significant p values shown. (B) ROC curve, comparing ICI-nephritis cases and ICI-treated controls (pink triangles) or hemodynamic AKI controls (blue circles), respectively. Area under the curve (AUC), 95% CI, and p value shown. AKI, acute kidney injury; ANOVA, analysis of variance; ICI, immune checkpoint inhibitor; ULN, upper limit of normal.