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. 2023 Jan 19;11(1):e006222. doi: 10.1136/jitc-2022-006222

Figure 3.

Figure 3

Peripheral blood T cell markers are altered in ICI-nephritis. (A, B) T cell subsets, shown as absolute count in log scale or CD4+/CD8+ratio and compared between ICI-treated controls (N=6; squares) and ICI-nephritis (N=19; circles). Symbols represent unique individuals; bars represent geometric means (95% CIs) of total indicated patients. Red dotted lines indicate the lower limit of normal of the assay. ns=non-significant. (C) ROC curves of absolute (cells/μL) total CD8+T cells (left) and naïve CD45RA+CD8+ T cells (right). Area under the curve (AUC), 95% CI, and p values shown. (D) Linear correlation between total CD8+T cell count and CD45RA+CD8+ T cell count. R2 and p value are shown in the graph. Symbols represent unique individuals; straight line represents fitted regression line. ICI, immune checkpoint inhibitor; ns, not significant; ROC, receiver operating characteristic.