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. 2023 Jan 19;11(1):e006222. doi: 10.1136/jitc-2022-006222

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Peripheral blood B cell markers are altered in ICI-nephritis. (A–C) B cell subsets, shown as absolute count in log scale, plasmablasts as % total CD19+B cells, or out-of-range B cells as % total unique individuals as indicated and compared between ICI-treated controls (N=6; squares) and ICI-nephritis (N=19; circles). Symbols represent unique individuals; bars represent geometric means (95% CIs) of total indicated patients. Red dotted lines indicate the assay lower or higher limit of normal. ROC curve of absolute (cells/μL) peripheral memory B cells (CD27+CD19+) shown in 4C (right). Area under the curve (AUC), 95% CI, and p values shown. ICI, immune checkpoint inhibitor; ns, not significant; ROC, receiver operating characteristic.