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. 2023 Jan 19;11(1):e006222. doi: 10.1136/jitc-2022-006222

Figure 6.

Figure 6

Comparison of IL2RA gene expression, T cell receptor scores, and IL2 family signaling in kidney tissue. Gene expression data obtained from FFPE kidney biopsy tissue of patients with ICI-nephritis (N=22), other drug-induced nephritis (N=19), acute tubular necrosis (N=9), and histologically normal control biopsies (N=11). Gene expression shown by violin plot for IL2RA in log2 normalized count (A). IL-2 family signaling pathway score (B) and T cell receptor signaling pathway score (C). The pathway score is equal to the first principal component of the gene sets shown in online supplemental table 3. In all cases there was no significant difference between ICI-nephritis and other forms of AIN and the differences between AIN and ATN and healthy control were highly statistically significant. There was no significant difference between ICI-nephritis and other drug-induced nephritis. FFPE, formalin fixed, paraffin embedded; ICI, immune checkpoint inhibitor.