Table 1.

Comparison of the degrees of tumor-cell killing, enhancement of immune response (in vitro and/or in vivo), toxicity in vivo, and suppression of T cell proliferation among seven commercially available statin drugs

Drug	Tumor-cell killing	Enhancement of immune response	Toxicity in vivo	Suppression of T cell proliferation
Lovastatin	++	++	–	+
Simvastatin	++	++	–	++
Fluvastatin	+++	+	++	N/A
Pitavastatin	+++	–	++	N/A
Atorvastatin	+	–	N/A	N/A
Rosuvastatin	+	–	N/A	N/A
Pravastatin	+	+	N/A	N/A

Factors designated as not applicable were not tested.

+++, major effect; +, minor effect; –, no appreciable effect; ++, moderate effect; N/A, not applicable/tested.