Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 19;11(1):e005902. doi: 10.1136/jitc-2022-005902

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

The abundance and transcriptional profiles of MAIT cells in non-small cell lung cancer (NSCLC) patients based on scRNA-seq data (14 patients from GSE99254 and 11 patients from GSE162498). (A) t-Distributed Stochastic Neighbor Embedding (t-SNE) plot displaying 20 clusters identified on the basis of gene expression levels of CD3⁺ T cells in peripheral blood, tumor, and paratumor tissues from NSCLC patients. Cells are colored according to the 20 clusters defined in an unsupervised manner. (B) Expression of SLC4A10 in CD3⁺ T cells from peripheral blood, tumor and paratumor tissues of NSCLC patients. (C) Dot plot for markers characterizing MAIT cells with tumor-homing properties in NSCLC patients. The color intensity of each dot corresponds to the average gene expression across all cells in each cluster. (D) Dot plot for selected markers characterizing mucosal-associated invariant T (MAIT) cells with tumor-homing properties (cluster 12) that were reported previously.21 The color intensity of each dot corresponds to the average gene expression across all cells in each cluster. (E) Kaplan-Meier curves for disease-free survival (DFS) according to MAIT cell frequency in NSCLC patients from the TCGA database. (F) The top 10 enriched KEGG pathway of tumor enriched genes in MAIT cells from NSCLC patients. (G) The top 10 enriched KEGG pathway of paratumor enriched genes in MAIT cell from NSCLC patients. Survival analysis was determined by the log-rank (Mantel-Cox) test.