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. 2023 Jan 19;11(1):e005902. doi: 10.1136/jitc-2022-005902

Figure 5.

Figure 5

Functional alterations of circulating mucosal-associated invariant T (MAIT) cells in non-small cell lung cancer (NSCLC) patients who responded to anti-PD-1 therapy. Expression of HLA-DR (A), PD-1 (B), granzyme B (C), and IFN-γ (D), and IL-17A (E) in MAIT cells from peripheral blood of pretreatment NSCLC patients (HLA-DR, PD-1, n=26; IFN-γ, granzyme B, IL-17A, n=20), patients with progressive disease (PD) (HLA-DR, n=8; PD-1, n=18; IFN-γ, n=6; granzyme B, n=18; IL-17A, n=15), patients with stable disease (SD) (HLA-DR, n=11; PD-1, n=15; IFN-γ, n=11; granzyme B, IL-17A, n=15) and patients with complete response or partial response (CR/PR) (HLA-DR, n=18; PD-1, n=31; IFN-γ, n=16; granzyme B, IL-17A, n=29) detected by FCM (gated on CD3+ CD161+ TCR Vα7.2+) and their summary data. The upper and lower ends of the boxes represented IQR of values. The lines in the boxes represented median value. Statistical significance was calculated via Mann-Whitney U test or one-way ANOVA and Tukey multiple comparison tests. ANOVA, analysis of variance.FCM, flow cytometry.