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Transcription Factor Complexes in the Pulmonary Vasculature related to PAH. Overview of most relevant TF complex pathways in the pulmonary vasculature. TF complex formation upon complex inducing microenvironmental stimuli and downstream TF complex mediated gene transcription programs are shown. Yellow box represents nucleus. Blue box represents cell membrane. Dotted ovals indicate cell membrane anchored receptors. ub, Ubiquitin residue/Ubiquitination; –p, Phosphorylation.
