Figure 2. Variants in the PRNP Protein Coding Domain.

The gray bar represents the coding region of the PRNP gene. The darker gray section shows the location of the octapeptide repeat region. Black vertical lines refer to the position of called variants. These variants connect to plots, which show, first, the proportion of cases in each group with a variant at this position (bar plot, left y-axis) and, second, the allele frequency of these variants (scatter plot, right y-axis). Note that the scale of the y-axis varies between plots to aid data visualization. Codon 129 is not shown in this figure.