Fig. 5.

Compound 8 reduces calcium current through CaV2.2 and CaV3.2 channels expressed in HEK cells. Current density–voltage relationships from HEK cells transiently transfected with plasmid constructs encoding CaV1.2 and CaV1.3 channels (A left), CaV2.2 channels (B left); CaV3.1, CaV3.2, and CaV3.3 channels (C, left). The corresponding peak current densities are shown on the right of each I-V plot. Black symbols indicate overnight incubation with 0.1 % DMSO (control condition). Pink symbols indicate cells treated overnight with 20 µM of compound 8. p values as indicated, Student’s t-test.