Table 1.
Gating properties of total calcium currents recorded from DRG neurons.a
| Total Ca2+ | DMSO | Compound 8 | Compound 18 |
|---|---|---|---|
| Activation | |||
| V1/2 | 0.8 ± 1.4 (9) | 1.8 ± 2.0 (6) p = 0.904 |
1.8 ± 2.2 (7) p = 0.896 |
| k | 8.1 ± 1.2 (9) | 10.6 ± 1.8 (6) p = 0.468 |
8.0 ± 2.0 (7) p = 0.997 |
| Inactivation | |||
| V1/2 | −21.9 ± 1.6 (9) | −25.1 ± 1.0 (10) p = 0.187 |
−22.7 ± 1.7 (7) p = 0.89 |
| k | −13.6 ± 1.5 (9) | −9.8 ± 0.9 (10) p = 0.075 |
−10.6 ± 1.5 (7) p = 0.232 |
a
Values are mean ± SEM calculated from fits of the data from the indicated number of individual cells (in parentheses) to the Boltzmann equation: V1/2 midpoint potential (mV) for voltage dependence of activation or inactivation; and k slope factor. These values correspond to data shown in Fig. 2. No statistical differences were observed when compared with the control (DMSO). Data were analyzed with one-way ANOVA with Dunnett’s post hoc test. Abbreviations: DRG, dorsal root ganglia: DMSO, dimethyl sulfoxide.