Table 2.
Gating properties of N-type (CaV2.2) calcium currents recorded on DRG neurons.a
| N-type Ca2+ | DMSO | Compound 8 | p value |
|---|---|---|---|
| Activation | |||
| V1/2 | 2.1 ± 0.6 (11) | 2.2 ± 1.7 (8) | 0.931 |
| k | 5.6 ± 0.6 (11) | 8.2 ± 1.5 (8) | 0.134 |
| Inactivation | |||
| V1/2 | −24.3 ± 2.4 (11) | −20.2 ± 3.6 (8) | 0.37 |
| k | −17.6 ± 2.5 (11) | −17.4 ± 3.5 (8) | 0.966 |
a
Values are mean ± SEM calculated fitting the data from the indicated number of individual cells (in parentheses) to the Boltzmann equation: V1/2 midpoint potential (mV) for voltage dependence of activation or inactivation; and k slope factor. These values correspond to data shown in Fig. 3. No statistical differences were observed between groups. Data were analyzed with t-test with Welch’s correction. Abbreviations: DRG, dorsal root ganglia: DMSO, dimethyl sulfoxide.