Table 3.
Gating properties of T-type calcium currents recorded on DRG neurons.a
| T-type Ca2+ | DMSO | Compound 8 | p value |
|---|---|---|---|
| Activation | |||
| V1/2 | −27.1 ± 2.0 (10) | −20.2 ± 1.0 (8) | 0.007 |
| k | 9.2 ± 1.9 (10) | 5.7 ± 0.85 (8) | 0.113 |
| Inactivation | |||
| V1/2 | −59.9 ± 1.1 (10) | −56.5 ± 1.6 (8) | 0.098 |
| k | −8.2 ± 1.0 (10) | −9.8 ± 1.6 (8) | 0.404 |
a
Values are mean ± SEM calculated from fits of the data from the indicated number of individual cells (in parentheses) to the Boltzmann equation: V1/2 midpoint potential (mV) for voltage dependence of activation or inactivation; and k slope factor. These values correspond to data shown in Fig. 4. No statistical differences were observed between groups except for V1/2 of activation. Data were analyzed with t-test with Welch’s correction. Abbreviations: DRG, dorsal root ganglia: DMSO, dimethyl sulfoxide.