Table 5.

The comparison of the differentiation ability of TIC approach versus quantitative DCE approach.

Pairs		AUC of TIC	Highest AUC of a single microcirculation parameter	AUC of combined microcirculation parameters	P value
CP	PDAC pancreas	0.629	0.795	0.821	0.032*
CP	Normal control	0.984	0.981	1.000	0.353
PDAC pancreas	Normal control	0.991	0.993	1.000	0.353
CP	PDAC tumor	0.915	0.920	1.000	0.179
CP	Downstream	0.725	0.781	0.917	0.042*
CP	Upstream	0.625	0.792	0.722	0.380

For most pairs, the highest AUC produced by a single microcirculation parameter is higher than the AUC of TIC. The combination of the four microcirculation parameters outperforms the TIC analysis for all the pairs.

* indicates statistical significance.