TABLE 1.
Hippocampal metabolites detected by 1H-NMR spectroscopy that showed significant differences between control and Tg rats.
| Metabolite | FRD | |||
|---|---|---|---|---|
| Tg+/- | Tg+/+ | Tg−/+ | Tg+/+ | |
| NAD | 2,50E-06 | 8,36E-11 | ↓ | ↓ |
| Nam | >0.05 | 3,20E-05 | = | ↑ |
| Taurine | 2,39E-06 | 2,70E-05 | ↓ | ↓ |
| Valine | 1,71E-02 | >0.05 | ↓ | = |
| GSH | >0.05 | 2,08E-02 | = | ↑ |
| Tyrosine | >0.05 | 2,47E-02 | = | ↑ |
| NAA | 3,55E-02 | >0.05 | ↓ | = |
| Creatine | 3,55E-02 | >0.05 | ↓ | = |
| Glutamate | 4,59E-02 | 4,80E-02 | ↓ | ↓ |
Differences in the AUC, of metabolites were analyzed by one-way ANOVA, with Fisher’s LSD, post-hoc test; FDR, false discovery rate. Arrows indicate significant increase (up) or decrease (down) with respect to control rats. = , no change from control rats. NAD, nicotinamide adenine dinucleotide; Nam, nicotinamide; GSH, glutathione; NAA, N-acetylaspartate.