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. 2023 Jan 6;10:946544. doi: 10.3389/fpubh.2022.946544

Table 3.

Models estimated mean direct medical costs (including percentage change compared to Stage I), Euros 2021.

Model estimated Mean cost - Germany
(% increase compared to Stage I)
Lemhouer et al. (48) – Belgium (% increase compared to Stage I)* Sun L. et al (4) – Systematic review (% increase compared to Stage I)** Capri and Russo (15) - Italy (% increase compared to Stage I) Harfouche et al. (17) - Portugal
(% increase compared to Stage I)
Brandao et al. (49) - Portugal
(% increase compared to Stage I)
DCIS €9,838 €9,063 €9,744 €5,429
Stage I €21,523 €17,624 €24,586 €9,361 €8,586 €9,796
Stage II €25,679 (19.3%) €25,209 (43%) €32,525 (32%) €11,169 (19%) €13,786 (60%) €13,839 (41%)
Stage III €30,156 (40.1%) €30,985 (76%) €47,831 (95%) €13,952 (49%) €16,755 (95%) €15,957 (63%)
Stage IV €42,086 (95.5%) €7,581* €51,372 (109%) €13,318 (42%) €20,478 (138%) -

DCIS, Ductal Carcinoma In Situ. *only two patients in Stage IV for cost estimation **The cumulative mean of all studies included in the systematic review (nine studies from US, four from European Union, and eight from other countries world-wide). Source: Authors' elaboration.