TABLE 5.
Summary of the Norwegian society of rheumatology’s recommendations on diagnosis and treatment of patients with giant cell arteritis (GCA).
# of recommendation | |
1 | Refer patients suspected of having GCA to a Fast-Track GCA clinic (19) or a rheumatologist within 24 h. Treatment should not be delayed while waiting for this evaluation. |
2 | Obtain a thorough history and perform clinical examination and laboratory work up. |
3 | In patients with high clinical suspicion of GCA and a positive diagnostic test (temporal artery biopsy or any imaging modality) no further test is required to confirm the diagnosis. |
4 | Perform ultrasound of temporal and axillary arteries using high-end ultrasound equipment. Ultrasound of facial artery increases the sensitivity (32). If ultrasound is not available or inconclusive, perform another diagnostic test. |
5 | Refer to ophthalmologist if visual manifestations. |
6 | Initiate treatment with 40 mg Prednisolone/day in patients without visual manifestations. Initiate treatment with Prednisolone 60 mg/day if visual manifestations are present, consider a single dose of 500 mg IV methylprednisolone. |
7 | Taper daily Prednisolone dose as described in Table 6. |
8 | In minor relapse: Increase Prednisolone dose to the most recent effective dosage. In refractory disease or major relapse: Initiate Methotrexate (MTX) 20 mg/week sc. Consider Tocilizumab (TCZ) 162 mg/week sc if the patient is not tolerating or has a refractory or relapsing disease while on MTX. |
9 | Patients with GCA and high risk for osteoporosis should receive treatment according to the Norwegian guidelines for osteoporosis diagnostics and treatment. |
10 | Acetylsalicylic acid should not be used routinely, and should be considered on individual indication. |
11 | A relapse should be confirmed by an imaging modality. Modified Kerr’s (NIH criteria) could be used to monitor disease activity (31). |
12 | Reevaluate the diagnosis in patients not responding to standard treatment. |
13 | Follow-up should be performed every month until remission is achieved, and then after 3 months, 6 months, and yearly. |