Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cmpd1 and Cmpd2 bind to TB LeuRS via an adenosine-dependent mechanism. (a, b) Chemical structures of the two antituberculosis LeuRS inhibitors, Cmpd1 and Cmpd2. (c) ITC titration of compounds into TB LeuRS shows no binding. (d, e) ITC titrations of Cmpd2 and Cmpd1 into TB LeuRS in the presence of AMP, showing potent nanomolar affinities. AMP concentration was kept at physiological levels (10 mM).
