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. 2023 Jan 6;13:1089064. doi: 10.3389/fimmu.2022.1089064

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Copyright © 2023 Gong, Worley, Carver, Goldstein and Deng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutrophils are responsible for the early induction of pulmonary vascular leakage in MHV-1 infected A/J mice. (A) MPO was significantly reduced in BAL fluid from 1A8-treated A/J mice compared to 2A3-treated A/J and 2A3-treated B6 mice, showing a reduction in neutrophil activity. (B) IgM was measured from BAL fluid samples and 1A8-treated A/J mice had lower levels of IgM compared to isotype antibody-treated A/J mice. IgM levels from 1A8 mice were equal to those found in the B6 mice groups. (C) Following neutrophil depletion, viral load was measured via plaque assay from lung samples. Neutrophil depletion had no effect on viral burden in the lungs of either B6 or A/J mice. Data shown are pooled data from 2 replicate experiments. Statistical analysis by Mann-Whitney U tests. Significant differences are denoted *p < 0.05, **p < 0.01, ***p < 0.001; “ns” p>0.05 (not significant).