Figure 2.

Overview of the CTCs detection technologies and the potential clinical applications of CTCs in CRC. CTCs isolation can usually be divided into two groups: physical isolation designed to exploit the differing physical belongings of blood components, such as size, deformity, and charge; and biological isolation, often utilizing antibody-based capture methods to enrich CTCs or deplete various blood cells. Following isolation, CTCs are open to a variety of downstream applications, focusing primarily on one of three categories: enumeration, characterization, and expansion.