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. 2023 Jan 6;12:1023565. doi: 10.3389/fonc.2022.1023565

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Copyright © 2023 Mirza, Bhadresha, Mughal, McCabe, Shahbazi, Ruff and Penny

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of CAFs in CRC. A numeral of biomarkers that are extremely expressed in CAFs, like α-SMA, fibroblast activation protein alpha (FAP), fibroblast-specific protein 1 (FSP-1), platelet-derived growth factor receptor-α (PDGFRα) and PDGFRβ have now been commonly used to classify or isolate CAFs from the pool of fibroblasts present in the whole body. Described genes and proteins showed poorer disease progression, recurrence-free survival, and overall survival. Taken together, these markers could be used as liquid biopsy approach for early detection and treatment prognosis in CRC patients.