Figure 6.

The impact of immune infiltrates on CRC. In CRC, immune infiltrates can impact CRC cell death, either directly or via tumoricidal T cells (TCT), and consequently affect tumor progression. For example, cytotoxic T cells, macrophages, and NK cells can exert a cytolytic effect on CRC cells. For other populations of cells, such as Treg, B cells, dendritic cells, or M2-like macrophages, generally impact CRC cell death by mediating the tumoricidal activity of TCT cells. Herein, Treg, regulatory B cells, immature dendritic cells, and macrophages enable TCT cells to be exhausted, thus causing substantial progression in CRC tumors. Accordingly, immunoscore system using immune cells could deliver insights into a novel liquid biopsy approach as a diagnostic tool.