Table 2.

Non-invasive biomarkers (miRNA, Proteins, lnc RNA and circ-RNA) used for CRC detection till date.

Circulating nucleic acids and proteins in CRC
Sample	miRNA	Protein	lncRNA	Circ-RNA
Plasma	miR-125a-3p, miR-193a-5p, miR-320c, miR-23b, miR-27a, miR-760, miR-130a, miR-29a, miR-210-3p, miR-92a, miRNA-18a, miR-100, miRNA-19a, miR-30e, miRNA-335, miR-16, miRNA-29a, miR-144-5p, miRNA-15b, let-7i, miRNA-19b, miR-486-5p, miR-20a, miR-181a-5p, miR-155, miR-30d-5p, miR-21, miR-24, miR-92, miR-29b, miR-106a, miR-194, miR-200c, miR-320a, miR-372, miR-375, miR-96, miR-423-5p, miR-92a, miR-601, miR-221, miR-760, miR-182, miR-320d, miR-506, miR-7, miR-4316, miR-93, miR-223, miR-31, miR-1290, miR-181b, miR-431, miR-203, miR139-p3, miR-139-3p, miR-409-3p, miR-18a, miR-22, miR-25, miR-29, miR-19a, miR-19b, miR-15b, miR-29a, miR-335, let-7g, miR-15b-5p, miR-18a-5p, miR-29a-3p, miR-335-5p, miR-19a3p, miR-19b3p	CPNE3 CEA Melanotransferrin	LNCV6_116109 LNCV6_98390 LNCV6_38772 LNCV_108266 LNCV6_84003 LNCV6_98602 91H PVT-1 MEG3 ATB CCAT1	circ-133 circPACRGL circ-ABCC1 circ_0000338 ciRS-122 hsa_circ_0004585 circ-FBXW7
Serum	miR-17-92a, miR-99b-5p, miR-19a, miR-150-5p, miR-1229, miR-548c-5p, miR-25-3p, miR-638, miR-17-5p, miR-33a-5p, miR-92a-3p, miR-210-3p, miR-135a-5p, miR-208b, miRNA-21, miR-139-3p, miRNA-31, miR-145, miRNA-92a, mir-92a, let-7g, miR-143, miRNA-181b, miR-21-5p, miRNA-203, miR-21, miR-96, miR-221, miR-139a-5p, miR-196b, miR-338-5p, miR-210, miR-1290, miR-103, miR-720, miR-106a, miR-17-3p, miR-92, miR-125, miR-223, miR-20a, miR-150, let-7a, miR-4516	FOXD2-AS1, QSOX1, NRIR, PKM2, LOC_009459, NNT-AS1, H19, CCAL, UCA1, HOTTIP, PrP(C), CA11-19, MIC-1 (GDF15), IL-6, IL-8, Growth-related gene, product β1, Cyr61, B6-integrin, TIMP-1, RBP4, THBS2, TFF3, COL3A1, COL10A1, AZGP1, Angiopoietin-2 7, Kininogen	CCAT1 UCA1 HOTAIR LOC285194 Nbla12061 RP11-462C24.1 BLACAT1	circ_0004771 circFMN2
Stool	miR-21, miR-29a, miR-135, miR-224, miR-92a, miR-7, miR-938, miR-222, miR-146a, miR-143, miR-138, miR-127-5p, miR-29b, miR-9, iR214, miR-199a-3p, miR-196a, miR-183, miR-17, miR-20a, miR-96, miR-106a, miR-134, miR-135b, miR-221, miR-18a, miR-223, miR-451, miR-144, miR-17-3p, miR-135b-5p, miR-421, miR-27a-3p	Haemoglobin (FIT) M2-PK MMP 9