Table 1.

Demographics, clinical presentation, treatment and outcomes in patients with CVST post-vector-based SARS-CoV2 vaccines administration

Author	Age and gender	Presenting symptoms	Duration between vaccination and symptom onset	Administered vaccine	Lowest platelet count (109/L)	Clotting screen on admission	Peak D-Dimer levels	PF4 antibody ELISA	Neuroimaging findings	Extracranial thrombosis	Treatment	Residual neurologic deficits
Our case report	28 M	Headache Blurry vision Diplopia Photophobia	10 days	Ad26.COV2.S	63	PT: 18.3 INR: 1.5 APTT: 36.3	22 546	Positive	Thrombosis of superior sagittal and right transverse sinuses, and right IJV	Right segmental and subsegmental PE, Right hepatic vein thrombosis	Argatroban, dabigatran, and IVIG	Recovery with no residual neurologic deficits
Graf	29 M	Headache Aphasia Apraxia	9 days	ChAdOx1 nCoV-19	32	NA	65.7	NA	Left transverse, sigmoid sinuses and IJV thrombosis, Temporo-parietal ICH	Mesenteric and portal vein thrombosis	Argatroban and IVIG	Aphasia improved
Soleimani	34 M	Headache Photophobia Hemiparesis	13 days	ChAdOx1 nCoV-19	23	PT: 14.8 INR: 1.5 APTT: 23.9	37 293	Positive	Superior sagittal, bilateral transverse sinuses, and left vein of Trolard thrombosis, Right sided midline shit and uncal herniation	Right lower lobe segmental PE	PLEX, IVIG, argatroban, decompressive hemicraniectomy	Right hemiparesis and aphasia
Soleimani	59 F	Headache Hemiparesis Sensory loss Neglect Seizure	14 days	ChAdOx1 nCoV-19	18	PT: 14.5 INR: 1.2 APTT: 24.4	38 588	Positive	Superior sagittal and right transverse sinus thrombosis, Frontal hematoma and midline shift.	Thrombosed right hepatic vein and right lower lobe pulmonary emboli	IVIG, IVSM, argatroban, and decompressive hemicraniectomy	Left hemiparesis
Soleimani	39 F	Headache Photophobia	10 days	ChAdOx1 nCoV-19	63	PT: 15.1 INR: 1.1 APTT: 33.2	20 289	Negative	Left transverse, sigmoid, and sagittal sinuses and jugular venous thrombosis	None	IVSM, PLEX and argatroban	None
Zanferrari	40 F	Headache Aphasia Hemiparesis	8 days	ChAdOx1 nCoV-19	27	APTT: 24.9	27 546	Positive	Left sigmoid, transverse rectus and inferior longitudinal sinuses thrombosis	None	Fondaparinux and IVIG	None
Castelli	50 M	Headache Vision loss Hemiparesis	11 days	ChAdOx1 nCoV-19	20	NA	>10 000	Negative	Left hemisphere ICH, and lack of opacification of the left transverse and sigmoid sinuses, Uncal herniation	None	Bilateral decompressive craniectomy	Death
De Michele	57 W	Hemiparesis Gaze deviation Dysarthria Neglect	9 days	ChAdOx1 nCoV-19	23	NA	elevated	Positive	Right MCA infarct	None	IV steroids IVIG Decompressive craniectomy	Critical condition
De Michele	55 W	Aphasia Hemiparesis Seizures Coma Abdominal pain	10 days	ChAdOx1 nCoV-19	59	NA	elevated	Positive	Right ICA and bilateral MCA occlusion, Uncal herniation	Portal vein thrombosis, Left lower lobe subsegmental PE	IVIG, and IV steroid	Death

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