Table 1.
Continued
| Author | Age and gender | Presenting symptoms | Duration between vaccination and symptom onset | Administered vaccine | Lowest platelet count (109/L) | Clotting screen on admission | Peak D-Dimer levels | PF4 antibody ELISA | Neuroimaging findings | Extracranial thrombosis | Treatment | Residual neurologic deficits |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bayas | 55 W | Chemosis Orbital pain Diplopia Hemiparesis Aphasia Seizure | 10 days | ChAdOx1 nCoV-19 | 30 | NA | NA | Positive | Superior ophthalmic vein thrombosis. Ischemic stroke in the MCA territory | None | IV steroids | NA |
| D’Agostino | 54 W | Confusion | 12 days | ChAdOx1 nCoV-19 | NA | PT: 33.2 APPT: 41 | elevated | NA | Right frontal and temporal lobes ICH, Right superior longitudinal sinus, vein of Galen and superior sagittal thrombosis | Floating thrombus within the aortic arch. | Balloon angioplasty of the right coronary artery | Death |
| Blauenfeldt | 60 W | Headache Abdominal pain Confusion | 7 days | ChAdOx1 nCoV-19 | 5 | INR: 1 APPT: 28 | 106 200 | Negative | Infarction in the right MCA territory | None | Platelet concentrate | Death |
| Wolf | 22 W | Headache Seizure | 4 days | ChAdOx1 nCoV-19 | 75 | NA | 2590 | Positive | SAH, superior sagittal, left transverse and sigmoid sinuses thrombosis | None | Enoxaparin, followed by dabigatran | None |
| Wolf | 46 F | Headache Aphasia Homonymous hemianopia | 8 days | ChAdOx1 nCoV-19 | 60 | NA | 22 800 | Positive | Superior sagittal, transverse and sigmoid sinuses thrombosis, acute left occipital lobe ICH. | None | Rheolysis via balloon angioplasty, Enoxaparin followed by danaparoid, followed by dabigatran | Mild residual deficits (mRS 1) |
| Wolf | 36 F | Headache Aphasia Confusion | 7 days | ChAdOx1 nCoV-19 | 92 | NA | 2120 | Positive | Thrombosis of the straight and superior sagittal sinuses, Bilateral thalamic edema | None | Danaparoid, followed by Enoxaparin, and dabigatran | None |
| Mehta | 32 M | Headache Hemiparesis Ataxia | 9 days | ChAdOx1 nCoV-19 | 30 | NA | NA | NA | Superior sagittal sinus and cortical vein thrombosis and significant cortical oedema with small areas of parenchymal and SAH | None | None | Death |
| Mehta | 25 M | Headache Photophobia Vomiting Rash Gum bleeding Hemiparesis Ataxia | 6 days | ChAdOx1 nCoV-19 | 19 | NA | NA | Positive | Superior sagittal sinus thrombosis extending into the cortical veins, SAH and ICH | None | IV unfractionated heparin, platelet transfusions, IV dexamethasone, IVIG | Death |
| Suresh | 27 M | Headaches Vomiting Homonymous hemianopia | 2 days | ChAdOx1 nCoV-19 | 73 | PT: 12.9 APTT: 27.5 | 34 071 | Positive | Right transverse venous sinus thrombosis, ICH in the right parietal lobe | None | IVIG Dabigatran Prednisone | Death |
(Continued)