Table 1.
Continued
| Author | Age and gender | Presenting symptoms | Duration between vaccination and symptom onset | Administered vaccine | Lowest platelet count (109/L) | Clotting screen on admission | Peak D-Dimer levels | PF4 antibody ELISA | Neuroimaging findings | Extracranial thrombosis | Treatment | Residual neurologic deficits |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| George | 40 W | Headache | 7 days | Ad26.COV2.S | 20 | APTT: 26.4 | 27 150 | Negative | Left transverse and sigmoid sinuses thrombosis | Right PE | Bivalirudin IVIG | Recovery with no residual neurologic deficits |
| Muir | 48 W | Malaise Abdominal pain | 14 days | Ad26.COV2.S | 13 | APTT: 41 | 117 500 | Positive | Right transverse and straight sinuses thrombosis | Splanchnic, right hepatic and splenic venous thrombosis | Heparin switched to argatroban and IVIG | Patient remained in critical condition |
| See | ≥40 F | Headaches Hemiparesis | 6 | Ad26.COV2.S | 43 | INR: 1.4 APTT: 31 | >20 | NA | Right transverse, sigmoid and Left IJV thrombosis, Right temporoparietal ICH | None | NA | NA |
| See | 18–39 F | Headaches Aphasia | 9 | Ad26.COV2.S | 78 | INR: 1.2 APTT: 22.3 | 1.1 | Positive | Left transverse, sigmoid sinus, confluence of sinuses, and straight sinus thrombosis, Left temporal lobe ICH | None | NA | NA |
| See | 18–39 F | Headaches Hemiparesis Gaze deviation Neglect Seizure | 8 | Ad26.COV2.S | 18 | INR: 1.5 APTT: 31.1 | 8.46 | Positive | Superior and inferior sagittal, straight sinuses and cortical venous thrombosis, Bilateral frontal ICH, right SAH and IVH | None | NA | NA |
| See | 18–39 F | Headaches | 8 | Ad26.COV2.S | 127 | INR: 1.1 APTT:31.2 | 5.45 | Positive | Right transverse and sigmoid sinuses thrombosis | Portal vein thrombosis and right pulmonary embolus | NA | NA |
| See | 18–39 F | Headaches | 6 | Ad26.COV2.S | 10 | INR: 1.1 APTT: 18.1 | 7.05 | Positive | Right transverse and sigmoid sinuses thrombosis | Bilateral lower extremity DVT | NA | NA |
| See | ≥40 F | Headache | 13 | Ad26.COV2.S | 13 | INR: 1.2 | 112.07 | Positive | Right transverse and straight sinuses thrombosis, Right IVJ thrombosis, Right occipital ICH | Portal, splenic, right hepatic, distal superior mesenteric venous thrombosis, Right posterior tibial and peroneal DVT | NA | NA |
| See | 18–39 F | Headache Photophobia | 15 | Ad26.COV2.S | 64 | INR: 0.9 APTT: 28 | 7.84 | Positive | Superior sagittal, transverse, straight and sigmoid sinuses thrombosis, Right IJV thrombosis | None | NA | NA |
(Continued)