Table. Amino acid differences identified between the highly pathogenic avian influenza A(H5N1) viruses from minks (n = 4) and the most closely related H5N1 viruses in Europe (n = 18), May–October 2022 .
| Viruses | Amino acid mutations | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PB2 | PB1 | PA | HA | NA | M2 | NS2 | PB1-F2 | |||||||||
| 271 | 451 | 658 | 175 | 181 | 317 | 388 | 86 | 665 | 390 | 74 | 163 | 396 | 31 | 43 | 30 | |
| A/Mink/Spain/3691–8_22VIR10586–10/2022 | A | V | Y | N | I | V | R | T | L | M | S | L | M | N | G | L |
| A/Mink/Spain/3691–10_22VIR10586–11/2022 | A | V | Y | N | I | V | R | T | L | M | S | L | M | N | G | L |
| A/Mink/Spain/3691–2_22VIR10586–8/2022 | A | V | H | N | I | V | R | T | L | I | S | L | M | N | G | L |
| A/Mink/Spain/3691–3_22VIR10586–9/2022 | A | V | Y | N | I | V | R | T | M | I | S | L | M | N | G | L |
| A/Eurasian_Curlew/Netherlands/2/2022 | T | nd | Y | D | I | M | K | M | L | I | F | V | I | S | D | P |
| A/European_Herring_Gull/Netherlands/5/2022 | T | nd | Y | N | I | M | K | M | L | I | F | V | M | N | D | P |
| A/European_Herring_Gull/Netherlands/6/2022 | T | nd | Y | D | I | M | K | M | L | I | F | V | I | S | D | P |
| A/European_Herring_Gull/Netherlands/7/2022 | T | nd | Y | N | I | M | K | M | L | I | F | V | M | N | D | P |
| A/European_Herring_Gull/Netherlands/9/2022 | T | nd | Y | N | I | M | K | M | L | I | F | V | M | N | D | P |
| A/European_Herring_Gull/Netherlands/12/2022 | T | nd | Y | D | M | M | K | M | L | I | F | V | I | S | D | P |
| A/European_Herring_Gull/Netherlands/13/2022 | T | nd | Y | N | I | M | K | M | L | I | F | V | M | N | D | P |
| A/European_Herring_Gull/Netherlands/14/2022 | T | nd | Y | N | I | M | K | M | L | I | F | V | M | N | D | P |
| A/European_Herring_Gull/Netherlands/18/2022 | T | nd | Y | D | M | M | K | M | L | I | F | V | I | S | D | P |
| A/Common_Tern/Netherlands/26/2022 | T | nd | Y | D | M | M | K | M | L | I | F | V | I | S | D | P |
| A/Larus_argentatus/Belgium/9013_0001/2022 | T | I | Y | N | I | M | K | M | L | I | F | V | M | N | D | P |
| A/Vulpes_vulpes/Belgium/9031_0008/2022 | T | I | Y | D | M | M | K | M | L | I | F | V | I | S | D | P |
| A/gull/France/22P015977/2022 | T | V | Y | N | I | M | K | M | L | I | F | V | I | S | D | P |
| A/European_Herring_Gull/Netherlands/8/2022 | T | nd | Y | D | M | M | K | M | L | I | F | V | I | S | D | P |
| A/European_Herring_Gull/Netherlands/15/2022 | T | nd | Y | D | M | M | K | M | L | I | F | V | I | S | D | P |
| A/European_Herring_Gull/Netherlands/19/2022 | T | nd | Y | D | M | M | K | M | L | I | F | V | I | S | D | P |
| A/European_Herring_Gull/Netherlands/20/2022 | T | nd | Y | D | M | M | K | M | L | I | F | V | I | S | D | P |
| A/Gallus_gallus/Belgium/9548_0001/2022 | T | I | Y | D | M | M | K | M | L | I | F | V | I | S | D | P |
| References | [7] | nr | nr | nr | nr | nr | nr | nr | nr | nr | nr | nr | nr | [16] | nr | nr |
nd: not determined; nr: no reference.
Viruses represented were collected between May and October 2022 from the Netherlands (n = 14), Belgium (n = 3), France (n = 1) and Spain (minks; n = 4). Mutations identified only in samples from minks are highlighted in bold.